When formulating high-end products, high potent actives aren’t the only factors to consider, your formulation needs to be in a suitable vehicle with ingredients that complement and enhance your potent actives. Enhance penetration and the bioavailability of your specialiseed active to get effective results. Bioavailability is the rate at which an active can penetrate the epidermis to get to where it is needed. Of course, there are certain formulas you want to sit on the skin. However, when it comes to getting potent ingredients well past the first layers, these 8 Ingredients can help you get the job done: We have picked these 8 carefully because of their multipurpose properties.
MSM
Size matters! MSM (MethylSulfonylMethane) has a really small molecule size, and that’s one way this beauty helps enhance penetration. Due to its absorption enhancement properties, it is a very good ingredient to increase the bioavailability of your active. It is a very good multifunctional active that can be enjoyed in many product types.
OTHER BENEFITS
• Brightening
• Anti-Ance
• Anti-aging
• Wound healing support
• Hydrating
ALPHA BISABOLOL
Soluble in oil and alcohol, a component of calming chamomile it can also reduce potential irritation of formulas as well as calm active inflammation. A good ingredient to pair with your skin lightening formulations that can also enhance penetration of other actives.
• Soothing
• Anti-Inflammatory
• Skin Brightening
PROPYLENE GLYCOL
This humectant is small and can be used to replace glycerin minus the sticky effect! Humectants increase the water holding capacity of the stratum corneum (SC) and when the SC swells, isn’t makes it easier for actives to pass through. Propylene Glycol helps draw actives passed the stratum corneum. That’s why it is combined in many extracts solutions.
• Solvent
• Humectant
SILK PEPTIDE
What’s not to love about silk peptides? They can go right to the bottom layer of the epidermis and activate signal molecules. We recently posted a formula for Japanese Sake and Silk Toner. If you haven’t already seen it, check it out.
• Humectant
• Moisturizing
• Anti-aging
• Smoothing
EPIDEV (AKA Dimethyl Isosorbide)
Why we love Epidev
1. Its both water-soluble and oil-soluble – it’s got the premium ticket on each layer of the skin!
2. The means that you can reduce the concentration of actives you use with this baby.
Epidev us very helpful when working with water-soluble actives – studies show that it increases permeation of the stratum corneum by 15%.
OTHER BENEFITS
• A natural ingredient derived from corn syrup – made specially for skincare.
• Water and Oil Soluble (most oils)
• Reduces irritation potential
• Prevents recrystallization of actives during transport.
• Improves the shelf life of active ingredients
Get Epidev here
GLYCOLIC ACID
This is the smallest in size of the AHA’s, but it packs a punch. May not be suitable for sensitive skin, since it potentiates the bioavailability of everything. Because it’s so small, it can squeeze it’s way deep into the skin and help carry your other actives. It also enhances delivery by the exfoliation of dead skin cells of the stratum corneum, making your skin softer, more hydrated and easier for actives to penetrate.
OTHER BENEFITS
• Evens out Skin Tone
• Brightens the Complexion
• Smoothens
• Exfoliates
OLEIC ACID
This natural fatty acid has a good affinity to the Stratum Corneum lipids and is known as a highly effective penetration enhancer. To enhance penetration Oleic acid is stronger when used in its 100% assay, however, oils high in oleic acid can also be used. The addition of oleic acid helps calm sensitive skin and elevate dryness. It also increased the penetration of salicylic acid by 28-fold in one in-vitro study. Avoid using this for acnegenic skin
OTHER BENEFITS
• Moisturizing
• Solvent
• Skin Softening
• Soothing
• Anti-Aging. Sez
AZONE OIL
Reported to be produced as the first penetration enhancer in skincare, azone is oil dispersible. Its non-greasy feel makes it ideal for aesthetic considerations. Compatible with organic solvents like propylene glycol and is effective on low concentrations between 1-3%
Other benefits
• Effective at low concentrations
• Non-greasy
• Solvent
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#Transdermaldelivery #skin #chemicalpenetrationenhancer #genesisformulab #Tidesmark
Knowledge is key! Didn’t know at MSM is a penetration enhancer. Thank you for tis . I appy